Research

Since 2012, the S4 Team has raised incredible awareness and more than $444,000 for CURE and epilepsy research. We are proud to announce that this year, Team S4 is sponsoring the regulation of cortical interneuron migration and epilepsy grant for Weill Cornell Medicine Medical College, Brain & Mind Research Institute (Read Letter from Natalia De Marco Garcia, Ph.D., March 2016).

Our fundraising efforts have also sponsored the CURE “Innovator Grant” awarded to Dr. Angelique Bordey at Yale University whose work may open an entirely new field of epilepsy research, as well as the CURE grant at Boston Children’s Hospital, where researchers’ findings could lead to the diagnosis and preventative treatment of individuals at risk from sudden unexpected deaths associated with seizures.

Read more about these grants below!

Natalia De Marco Garcia, Ph.D., Cornell University

Natalia De Marco Garcia, Ph.D., Cornell University

TEAM S4 AWARD, 2015 CURE RESEARCH AWARD
Natalia De Marco Garcia, Ph.D., Cornell University

“Regulation of cortical interneuron migration and epilepsy”

Many neurological illnesses including a subset of pediatric epilepsies are thought to arise during the development of the nervous system. Increasing experimental evidence points towards imbalances between the excitatory and inhibitory circuits in the brain as a prominent component in the generation of epilepsy. The goal of this proposal is to assess how environmental perturbations during a critical period of development affect inhibitory connections and lead to abnormal brain activity. We will focus our studies in a subset of inhibitory neurons since our previous work indicates that these neurons are exquisitely sensitive to environmental stress in newborns. We hope that our studies will inspire therapies to correct aberrant brain formation in epilepsy.

bordey

Angelique Bordey, Ph.D., Yale University

TEAM S4 AWARD, 2015 CURE RESEARCH AWARD
Angelique Bordey, Ph.D., Yale University

“Exosomes as carriers of circuit alterations in epilepsy”

This research aims at gaining novel insights into the biological processes that lead to cognitive deficits and psychiatric problems in children with epilepsy. More specifically, this work will examine whether the transfer of small vesicles (called exosomes) between abnormal brain cells leads to changes in the surrounding brain wiring. We will focus on abnormal “epileptic” neurons, like those found in focal cortical dysplasia and tuberous sclerosis complex, and will examine whether these cells alter the structure or electrical activity of healthy, neighboring neurons through the release of exosomes. If exosomes released from “epileptic” neurons do alter the function of healthy neurons, this would open up an entirely new field of epilepsy research.

David Paterson, Ph.D.,

David Paterson, Ph.D., Boston Children’s Hospital


TEAM S4 AWARD, 2013 CURE RESEARCH AWARD

David Paterson, Ph.D., Boston Children’s Hospital

“Searching for Common Gene Variants in Sudden Death in Childhood with Febrile Seizures, SIDS and SUDEP”

Sudden unexplained death in childhood associated with febrile seizures (SUDC-FS) is the sudden unexplained death of a child that has a personal and family history of fever-related (febrile) seizures. These children have many features in common with individuals dying of SUDEP and SIDS, including sleep-related death and discovery in the prone position. We believe that these diseases have similar causes including gene mutations that cause seizures. There is a clear pattern of genetic inheritance in some SUDC-FS families. Genetic analysis of these families, as proposed in this study, provides an excellent opportunity to identify the genes responsible for SUDC-FS and therefore also SUDEP and SIDS. This study has the potential, therefore, to uncover novel information that could be used to diagnose and treat all individuals at risk from sudden unexpected death associated with seizure.

Sarah presenting CURE Chair, Gardiner Lapham, with a $104,444 check for epilepsy research at the 2014 walk.

Sarah presenting CURE Chair, Gardiner Lapham, with a $104,444 check for epilepsy research at the 2014 walk.

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